Not in terms of like plot

because

who cares about what the plot is

Something about a virus wiping out humanity

What BioMega is about

is like

Blame! (same author) is about a sense of scale and supreme alienation in a world that has forgotten humanity

BioMega is aabout "what is the coolest thing that can happen on this page?"

"Let's do that"

The main character has won a quickdraw fight against 5 guys at once

One of the core cast is a talking bear

On the page I just linked he's using the explosions from a pair of missiles to launch his motorcycle into the air high enough to attack a fighter jet with his axe

It's just nonstop nonsense

Earlier he shot 13 ICBMs out of the sky with a rifle

I have NO idea where this is going and I barely care

it was a hell of a rifle

The talking bear has a hook for a hand

I'm glad the bear has clothes again