The ending of Clover Field, because they pretty much had no way of getting out of there.

The beginning of UP when they showed the life of that old guy and his childhood sweet heart.

From when they first met up to when they grew old and she died first and he was all alone. Very sad.

I remember they wanted a child together, but she couldn't have kids.

Maes Hughes funeral in FMA, the 2003 series, or the first series that's horrible compared to Brotherhood.

Ieyasu's ending in SB3.

E-123's ending in Sonic Adventure 1.

Sonic and Shadow's Chaos Control scene when they stopped the Ark from crashing into Earth. So epic it made me cry.

Kamina's death in Gurren Lagann.

The final fight in Gurren Lagann. So epic it made me cry.

The bathroom scene in Kimi ni Todoke between Sawako, Shizuru and Ayane.

The ending in SB season 2 when Hideyoshi died and he reached up into the sky and what fell out of his hands was the same necklace patch

Keiji had, which meant Nene gave one to both of them and that despite how Hideyoshi changed, he never stopped loving her and kept it.

Doctor Who, I don't watch it a lot but a day ago there was something about there being two Amy's and that they could only save one of them.

Because of some complications or whatever. It seemed very heartbreaking and unfair, but the older looking Amy gave herself up and died.