Sally: I think it'd be fair to say she has something of a lack of respect for it

Her standards are: I want to get laid, I find this person attractive, they are willing. Let's do this.

Other criteria such as "he's married" and "we're coworkers and it's probably a bad idea" aren't huge considerations.

Anita: Not necessarily for lack of trying, she just hasn't had the time.

Childrearing and superheroing and school and applying for colleges and Jesus Christ man she has no time

It's my headcanon that she's fooled around with a girl but it didn't go very far, but that may or may not ever be applicable.