yizang
4 years ago @Edit 4 years ago
有一篇關於 SARS-CoV-2 抗體對 COVID-19 保護力的研究非常有趣,是今年五月在 Nature Medicine 的論文:Delayed production of neutralizing antibodies correl...重點:保護力跟血液抗體濃度沒什麼關係,關鍵是生成抗體時機 —最好14天內!
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latest #6
yizang
4 years ago
"We observed a correlation between anti-spike (S) immunoglobulin G (IgG) levels, length of hospitalization and clinical parameters associated with worse clinical progression. Although high anti-S IgG levels correlated with worse disease severity, such correlation was time dependent."
yizang
4 years ago
"...high anti-S IgG levels correlated with worse disease severity, such correlation was time dependent. Deceased patients did not have higher overall humoral response than discharged patients. However, they mounted a robust, yet delayed, response, measured by anti-S, anti-receptor-binding domain IgG and neutralizing antibody levels compared to survivors."
yizang
4 years ago
"Delayed seroconversion kinetics correlated with impaired viral control in deceased patients."
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yizang
4 years ago
"Finally, although sera from 85% of patients displayed some neutralization capacity during their disease course, NAb generation before 14 d of disease onset emerged as a key factor for recovery."
yizang
4 years ago
"These data indicate that COVID-19 mortality does not correlate with the cross-sectional antiviral antibody levels per se but, rather, with the delayed kinetics of NAb production."
yizang
4 years ago
所以,台灣疫苗 EUA 審核標準只分析中和抗體濃度,其實是不夠的;有各種科學理由可以駁斥「免疫橋接」的現行手法,而現在又多了「何時產生抗體」這個重要要素。
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