If you were an invincible evil final boss except for this one thing that can be used to kill you (weapon, tome, wish-granting genie) and you can’t destroy it or get rid of it, what would you do with it?
Get agents I trust into whatever the local religion is and start destroying legends / prophecies of the macguffin, then replace them with similar-sounding legends of a completely unrelated red-herring item. Let the church safeguard that red herring, while the real one is kept in a personal vault.
That last one has all the hallmarks of getting in the ear of the scraggly hermit who publicly scoffs at the fake mcguffin and that the followers are “BLIND FOOLS”
With the real one, I might want to figure out the mechanism by which the invincibility is defeated, then use that to lock away the true macguffin, so that the only thing that can break the seal is what's inside said seal
Make a big show and dance about hiding my One Weakness at the bottom a very deadly and complex labyrinth filled with traps and monsters. Except that’s not really my One Weakness